
The article presents the results of the study of bone cytokines indicators, hormones of bone metabolism and the levels of thyroid autoantibodies and autoantibodies to type-specific collagens in 146 patients with joint hypermobility syndrome (JHS). The prevalence of vitamin D deficiency was significantly higher in patients with JHS compared to the control. The deviations of the bone mediators ratio in patients with JHS were identified. The study has demonstrated the increased incidence of autoimmune thyroiditis in patients with JHS and significantly more frequent existence of antithyroid antibodies and the antibodies to I-II types collagen
У 146 пациентов с синдромом гипермобильности суставов (СГМС) изучены показатели остеоактивных цитокинов, гормонов костного метаболизма, уровни аутоантител к тиреоидным антигенам и типоспецифическим коллагенам. Отмечена высокая распространенность дефицита витамина D у больных с СГМС по сравнению с контролем, а также нарушение соотношений медиаторов, регулирующих остеогенез и отражающих собственную эндокринную функцию кости. Исследование продемонстрировало повышенную частоту аутоиммунного тиреоидита при СГМС и достоверно более частое носительство антитиреоидных антител и аутоантител к коллагенам I и II типов.
СИНДРОМ ГИПЕРМОБИЛЬНОСТИ СУСТАВОВ,JOINT HYPERMOBILITY SYNDROME,КОСТНОЕ РЕМОДЕЛИРОВАНИЕ,BONE REMODELING,ЦИТОКИНЫ,CYTOKINES,АУТОИММУНИТЕТ,AUTOIMMUNITY,КОЛЛАГЕН,COLLAGEN
СИНДРОМ ГИПЕРМОБИЛЬНОСТИ СУСТАВОВ,JOINT HYPERMOBILITY SYNDROME,КОСТНОЕ РЕМОДЕЛИРОВАНИЕ,BONE REMODELING,ЦИТОКИНЫ,CYTOKINES,АУТОИММУНИТЕТ,AUTOIMMUNITY,КОЛЛАГЕН,COLLAGEN
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