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Использование таурина в лечении лекарственного поражения печени на фоне специфической терапии туберкулёза лёгких

Использование таурина в лечении лекарственного поражения печени на фоне специфической терапии туберкулёза лёгких

Abstract

Frequent development of drug-induced hepatitis in the background of specific therapy for tuberculosis requires enhanced methods and means of protecting the liver. This work investigates hepatoprotective antioxidant activity of taurine in patients with newly diagnosed pulmonary tuberculosis. The study excluded patients with viral hepatitis and alcohol abuse. Only for appropriate security controls of chemotherapy determination of alanine aminotransferase, aspartate aminotransferase is needed since other "routine" data are less informative. Drug liver damage was found in 68 % of patients treated with specific chemotherapy. The paper assesses the dynamics of biochemical indicators of the development of hepatic cytolytic syndrome. The authors proved that the optimal concurrent with specific therapy beginning hepatoprotective activities. For the prevention of drug liver recommended the appointment of standard-dose antioxidants (such as taurine) or hepatic, but the most effective are their combination. For the treatment of liver disease requiresa combination of antioxidant with hepatoprotector.

Частое развитие лекарственно-индуцированного гепатита на фоне специфической терапии туберкулеза требует расширения методов и средств защиты печени. Работа посвящена исследованию гепатопротекторной активности антиоксиданта таурина у больных с впервые выявленным туберкулезом легких. В исследование не включались пациенты, страдающие вирусными гепатитами и злоупотребляющие алкоголем. Лекарственное поражение печени выявлено у 68 % больных, получающих специфическую химиотерапию. В статье дана оценка динамики биохимических показателей, характеризующих развитие печеночного цитолитического синдрома. Авторами доказано, что оптимально одновременное со специфической терапией начало гепатопротекторных мероприятий. Для профилактики лекарственного поражения печени рекомендовано назначение стандартных доз антиоксидантов (например, таурина) или гепатопротекторов, наибольшей эффективностью обладает их комбинация. Для лечения поражения печени необходима комбинация антиоксиданта с гепатопротектором.

Keywords

ТАУРИН., TAURINE., АСПАРТАТАМИНОТРАНСФЕРАЗА, АЛАНИНАМИНОТРАНСФЕРАЗА, ЦИТОЛИТИЧЕСКИЙ СИНДРОМ, ГЕПАТОТОКСИЧНОСТЬ, ТУБЕРКУЛЕЗ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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