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Подход к диагностике фиброза печени: сывороточные маркеры

Подход к диагностике фиброза печени: сывороточные маркеры

Abstract

Фиброз печеночной ткани является завершающей стадией развития различ-ных заболеваний печени. Первоначально считалось, что фиброз необратим, но в настоящее время уже известно, что это динамический процесс, имеющий значи-тельный потенциал для обратного развития. Своевременная диагностика фиброза печени может предотвратить возникновение нежелательных осложнений. Традиционно диагностика и количественное определение фиброзированной ткани основывались на биопсии печени. Но у пункционной биопсии существует целый ряд недостатков, ограничивающих проведение этой процедуры. В данной статье рассматриваются современные методы оценки фиброза печени, основанные на определении сывороточных маркеров.

Hepatic fibrosis is the final stage of many disorders of the liver. Originally, hepatic fibrosis was considered irreversible, however, hepatic fibrosis is now known to be a dynamic process with a significant potential for resolution. Timely diagnosis of liver fibrosis can prevent development of unwanted complications. The diagnosis and quantitation of fibrosis have traditionally relied on liver biopsy. However, there are a number of drawbacks that limit its use. This article reviews the current methods of assessment of hepatic fibrosis based on the serum markers.

Keywords

сфиброз печени, сывороточные маркеры, fibrosis of liver; serum markers

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold