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МикроРНК MiR-21 и MiR-155 – новые маркеры рака молочной железы

МикроРНК MiR-21 и MiR-155 – новые маркеры рака молочной железы

Abstract

В клетке существует обширный класс регуляторных молекул, называемых микроРНК. В последнее время многие исследователи рассматривают микроРНК MiR-21 и MiR-155 в качестве новых потенциальных прогностических маркеров и мишеней для направленной терапии рака молочной железы (РМЖ). Обнаружено, что MiR-21 и MiR-155 регулируют метастатический потенциал опухолевых клеток и дифференциально экспрессированы в клетках РМЖ. Наш обзор посвящен теоретическим предпосылкам и практическим результатам исследований MiR-21 и MiR-155 в качестве потенциальных молекулярных маркеров РМЖ

N the cell there is a large class of regulatory molecules referred to as microRNA. Many investigators regard microRNA Mir and Mir-155 as new potential prognostic markers and targets for goal-oriented therapy for breast cancer (BC) these days. MiR-21 and MiR-155 have been found to regulate the metastatic potential of tumor cells and to be differentially expressed in the BC cells. Our review deals with the theoretical prerequisites for and practical results of studying MiR-21 and MiR-155 as potential molecular markers for BC.

Keywords

РАК МОЛОЧНОЙ ЖЕЛЕЗЫ, МИКРОРНК, СOX-2, СИГНАЛЬНЫЙ ПУТЬ TGF-B1/SMAD, МАРКЕРЫ, МИШЕНИ ДЛЯ НАПРАВЛЕННОЙ ТЕРАПИИ, TGF-B1/SMAD SIGNALING PATHWAY

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold