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Новые маркеры (cd160, CD200, LAIR-1) в диагностике В-клеточных лимфопролиферативных заболеваний

Новые маркеры (cd160, CD200, LAIR-1) в диагностике В-клеточных лимфопролиферативных заболеваний

Abstract

Проточная цитофлюориметрия используется в диагностике, классификации В-клеточных лимфопролиферативных заболеваний, оценке плотности таргетных антигенов и мониторировании остаточного опухолевого клона. Иммунофенотип опухолевых В-лимфоцитов не всегда соответствует его классической характеристике согласно иммуноморфологическому варианту лимфопролиферации, что затрудняет интерпретацию полученных результатов и указывает на необходимость поиска дополнительных информативных маркеров. Использование новых моноклональных антител к CD160, cD200, LAIR-1 расширяет диагностические возможности проточной цитофлюориметрии.

Flow cytometry is used for diagnosis and classification of B-cell lymphoproliferative disorders, measurement of target antigen expression, and residual tumor clone monitoring. An immunological phenotype of neoplastic B-cells does not always correspond to its classic features according to an immunomorphological type of lymphoproliferation that complicates the interpretation of the data obtained and indicates the need in search of additional informative markers. The use of new monoclonal anti-CD160-, anti-CD200-, and anti-LAIR-1-antibodies expands the diagnostic capabilities of flow cytometry.

Keywords

В-КЛЕТОЧНЫЕ ЛИМФОПРОЛИФЕРАТИВНЫЕ ЗАБОЛЕВАНИЯ, МАРКЕРЫ CD160, МНОГОПАРАМЕТРИЧЕСКАЯ ПРОТОЧНАЯ ЦИТОФЛЮОРИМЕТРИЯ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold