Powered by OpenAIRE graph
Found an issue? Give us feedback

Постстрептококковый артрит у подростков

Постстрептококковый артрит у подростков

Abstract

During 1995-1999 autumn-winter periods 300 teenagers with signs of acute respiratory disease (ARD) were examined. 38% from them had group A p-hemolytic streptococcus (GABS) and elevation of antistreptolysine-O antibodies titers what comply with definite streptococcal infection criteria. Arthritis was revealed and immunologically characterized in 35 teenagers with streptococcal pharyngitis. Pts with non streptococcal pharingitis did not have arthritis. These results allowed to describe clinical and immunological signs of poststreptococcal arthritis for the first time in our land. These signs included asymmetrical non migrating arthritis lasting from 8 to 156 days with primary involvement of large (knee) and less frequently small joints. Synovitis manifested with joint pain and swelling. It was confirmed by US examination and differed from migrating arthritis in acute rheumatic fever (ARF). According to WHO recommendations teenagers with definite streptococcal infection received combined treatment single injection of bicillin-5 with subsequent treatment with fenoximethylpenicilline. Cultures and blood immunologic examination in a month and later after treatment gave negative results in 90,5% of pts. Described disease or syndrome associated with acute upper respiratory infection in teenagers differ from ARF.

Обследование 300 подростков в осеннее-зимний период 1995-1999г.г. с признаками острого респираторного заболевания (ОРЗ) позволило выявить (5гемолитический стрептококк группы А (ГАБС) и повышенные титры антител к стрептолизину-О (АСЛ-О), что соответствует критериям истинной стрептококковой инфекции, у 38 % больных. У 35 подростков со стрептококковым фарингитом был выявлен, клинически и иммунологически охарактеризован артрит. В группе больных с фарингитом нестрептококковой этиологии не было зарегистрировано развития артрита. Клинически постстрептококковый артрит (ПСА) характеризовался как асимметричный и немигрирующий, продолжался от 8 до 156 дней, преимущественно поражал крупные (коленные), реже мелкие суставы, сопровождался артралгиями, припухлостью, имел УЗИ подтвержденный сииовиит и отличался от мигрирующего артрита при ОРЛ. Согласно рекомендациям ВОЗ, подростки с истинной стрептококковой инфекцией получили комбинированное лечение однократное введение бициллина-5 с последующим курсом феноксиметилпенициллина. Посевы и иммунологические исследования крови через 1 мес и более после лечения дали отрицательные результаты у 90,5% обследованных. Таким образом, описано заболевание или синдром, которое ассоциируется с острой инфекцией верхних дыхательных путей у подростков с ГАБС и отличается от РЛ.

Keywords

ПОСТСТРЕПТОКОККОВЫЙ АРТРИТ, ПОДРОСТКИ

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold