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Состояние гуморального иммунитета в парах «Мать-дитя» при гриппе а(Н3N2), перенесенном в первом триместре беременности

Состояние гуморального иммунитета в парах «Мать-дитя» при гриппе а(Н3N2), перенесенном в первом триместре беременности

Abstract

At full-term pregnancy the level of anti-influenza antibodies in 126 pairs “mother-child” at influenza A(H3N2) in the first trimester of gestation was studied. The first group (comparison) was made of 40 pairs “mother-child” at pregnancy not complicated with acute respiratory virus infection, but with exacerbation of somatic diseases as well as moderate and severe somatic and obstetric pathology. The second group consisted of 43 pairs “mother-child” with influenza infection with antibody titer 1:4-1:16; the third group had 41 pairs “mother-child” with influenza А(Н3N2) with antibody titer 1:8-1:32; the fourth group had 42 pairs “mother-child” with influenza infection (antibody titers were 1:32-1:128) associated with the threat of miscarriage at early stages of gestation. It was found out that in the second group in 80% of cases mothers had higher titers of anti-virus antibodies in comparison with the titers of their children; in 12.5% of cases there were equal titers of antibodies in maternal and umbilical blood. In the second and the third groups unlike the first one there was a tendency to the decrease of a number of pairs that had higher titers of antibodies in mothers and there was an increase of pairs with equal titers of anti-virus antibodies. In the fourth group the number of pairs with domination of titers of anti-influenza antibodies increased till 28.6% in children in comparison with the titers in their mothers (in the second group it was in 4.7%, р<0.05), which suggested antenatal infecting of full term newborns.

При доношенной беременности проводилось исследование уровня противогриппозных антител у 126 пар «мать-дитя» при гриппе А(Н3N2), перенесенном в первом триместре гестации. Первую группу (сравнения) составили 40 пар «мать-дитя» при беременности, неосложненной острой респираторной вирусной инфекцией, обострением соматических заболеваний, а также среднетяжелой и тяжелой соматической и акушерской патологией. Во вторую группу вошли 43 пары «мать-дитя» при гриппозной инфекции с титром антител 1:4-1:16, в третью 41 пара «мать-дитя» при гриппе А(Н3N2) с титром антител 1:8-1:32), а в четвертую 42 пары «мать-дитя» при гриппозной инфекции (титры антител 1:32-1:128), ассоциированной с угрозой невынашивания на ранних сроках гестации. Установлено, что во второй группе в 80% случаев у матерей обнаруживались более высокие титры противовирусных антител по сравнению с таковыми у их потомства, а в 12,5% равные титры антител в материнской и пуповинной крови. Во второй и третьей группах по сравнению с первой отмечалась тенденция к снижению количества пар, в которых определялись более высокие титры антител у матерей, а также к увеличению пар с равными титрами противовирусных антител. В четвертой группе до 28,6% возрастало количество пар с преобладанием титров противогриппозных антител у потомства по сравнению с таковыми у их матерей (во второй группе у 4,7%, р<0,05), что подтверждало антенатальное инфицирование доношенных новорожденных.

Keywords

ГРИПП А(Н3N2),ТИТРЫ АНТИТЕЛ,БЕРЕМЕННОСТЬ,ГУМОРАЛЬНЫЙ ИММУНИТЕТ,ДОНОШЕННЫЙ НОВОРОЖДЕННЫЙ,INFLUENZA A(H3N2),ANTIBODY TITERS,PREGNANCY,HUMORAL IMMUNITY,FULL TERM NEWBORN

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
bronze