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Определение IgG, связанного с тромбоцитами, у пациентов с тромбоцитопенией

Определение IgG, связанного с тромбоцитами, у пациентов с тромбоцитопенией

Abstract

The article presents the mode of detection of anti-thrombocyte auto-antibodies using flow cytometry technique. The values of IgG conjugated with thrombocytes are established in healthy persons. The rate of frequency of auto-antibodies to thrombocytes is analyzed in patients with primarily diagnosed immune thrombocytopenia, with relapse of disease and after therapy of immune thrombocytopenia. The carried out studies demonstrate that flow cytometry technique has a high sensitivity to detect thrombocyte-related antibodies and can be applied under examination of patients with thrombocytopenia.

Представлен способ определения антитромбоцитарных аутоантител методом проточной цитометрии. Установлены значения IgG, связанного с тромбоцитами, у здоровых людей. Изучена частота встречаемости аутоантител к тромбоцитам у пациентов с впервые диагностированной иммунной тромбоцитопенией (ИТП), с рецидивом заболевания и после терапии ИТП. Проведенные исследования демонстрируют, что метод проточной цитометрии обладает высокой чувствительностью для определения трамбоцитсвязанных антител и может использоваться при обследовании пациентов с тромбоцитопенией.

Keywords

ИММУННАЯ ТРОМБОЦИТОПЕНИЯ, ИТП, АНТИТРОМБОЦИТАРНЫЕ АУТОАНТИТЕЛА, ТРОМБОЦИТСВЯЗАННЫЙ IGG, ПРОТОЧНАЯ ЦИТОМЕТРИЯ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold