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Хронофармакологический принцип лечения пациентов с гипертонической болезнью

Хронофармакологический принцип лечения пациентов с гипертонической болезнью

Abstract

В настоящее время понятия хронобиологии и хронофармакологии играют все более важную роль в медицинской практике. В основе этих обоих понятий лежит представление о десинхронозе. Десинхронозом называется нарушение естественного хода биологических ритмов, их взаимной согласованности. Степень проявления десинхроноза соответствует тяжести течения заболевания, поэтому по состоянию суточных ритмов жизненных функций можно судить об активности и стадии патологического процесса. В полной мере это относится к сердечно-сосудистым заболеваниям (ССЗ), и в частности к гипертонической болезни (ГБ), сопровождающейся рассогласованием суточных ритмов гемодинамических параметров, экскреции вазоактивных веществ, участвующих в регуляции АД, как во времени, так и между собой. Сегодня исследования циркадных изменений артериального давления и частоты сердечных сокращений так же распространены, как и острые сердечно-сосудистые заболевания (инфаркт миокарда, острое нарушение мозгового кровообращения, внезапная смерть). Полученные результаты исследований вносят свои коррективы в терапевтические подходы лечения, подразумевая правильное использование гипотензивной терапии.

Currently, the notion of chronobiology and chronopharmacology play an increasingly important role in medical practice. The basis of these two concepts is the notion of DS. Desynchronosis called a violation of the natural course of biological rhythms, their mutual consistency. The degree of manifestation of DS corresponds to the severity of the disease, so as circadian rhythms vital functions can be judged on the activity and the stage of the pathological process. This fully applies to cardiovascular diseases (CVD) and, in particular, to essential hypertension (EH), accompanied by a mismatch of circadian rhythms of hemodynamic parameters, excretion of vasoactive substances involved in the regulation of blood pressure, both in time and among themselves. Today the study of circadian changes in blood pressure and heart rate are also common, as well as acute cardiovascular disease (myocardial infarction, cerebrovascular accident, sudden death). The results obtained are making adjustments to the therapeutic treatment approaches, implying the proper use of antihypertensive therapy.

Keywords

ХРОНОМЕДИЦИНА, ЦИРКАДИАННЫЙ ИНДЕКС, СУТОЧНОЕ МОНИТОРИРОВАНИЕ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ, ГИПЕРТОНИЧЕСКАЯ БОЛЕЗНЬ, ДЕСИНХРОНОЗ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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