
The influence of acute (2,5g/kg ethanol) and chronic 8-months alcohol intoxication in rats upon blood oxygen-transport function and prooxidant-antioxidant state of erythrocytes has been studied. In this study the increase of hemoglobin oxygen affinity, the development of oxidative stress under acute alcohol intoxication; the increase of hemoglobin oxygen affinity, the shift of acid-base condition of the blood to the alkalinity and the oxidative stress development during ethanol abolition under chronic alcohol intoxication of animals have been established.
В работе проведено изучение влияния острой (2,5 г/кг этанола) и хронической 8-месячной алкоголизации крыс на кислородтранспортную функцию крови и прооксидантно-антиоксидантный статус эритроцитов. Показано увеличение сродства гемоглобина к кислороду, развитие окислительного стресса при острой алкогольной интоксикации, увеличение сродства гемоглобина к кислороду, сдвиг кислотно-основного состояния крови в сторону алкалоза, развитие окислительного стресса в период отмены этанола при хронической алкоголизации животных.
КИСЛОРОДТРАНСПОРТНАЯ ФУНКЦИЯ, КРОВЬ, ПРООКСИДАНТНО-АНТИОКСИДАНТНЫЙ СТАТУС, ЭРИТРОЦИТЫ, АЛКОГОЛЬ
КИСЛОРОДТРАНСПОРТНАЯ ФУНКЦИЯ, КРОВЬ, ПРООКСИДАНТНО-АНТИОКСИДАНТНЫЙ СТАТУС, ЭРИТРОЦИТЫ, АЛКОГОЛЬ
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