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Кислородтранспортная функция крови и прооксидантно-антиоксидантный статус эритроцитов при острой и хронической алкогольной интоксикации крыс

Кислородтранспортная функция крови и прооксидантно-антиоксидантный статус эритроцитов при острой и хронической алкогольной интоксикации крыс

Abstract

The influence of acute (2,5g/kg ethanol) and chronic 8-months alcohol intoxication in rats upon blood oxygen-transport function and prooxidant-antioxidant state of erythrocytes has been studied. In this study the increase of hemoglobin oxygen affinity, the development of oxidative stress under acute alcohol intoxication; the increase of hemoglobin oxygen affinity, the shift of acid-base condition of the blood to the alkalinity and the oxidative stress development during ethanol abolition under chronic alcohol intoxication of animals have been established.

В работе проведено изучение влияния острой (2,5 г/кг этанола) и хронической 8-месячной алкоголизации крыс на кислородтранспортную функцию крови и прооксидантно-антиоксидантный статус эритроцитов. Показано увеличение сродства гемоглобина к кислороду, развитие окислительного стресса при острой алкогольной интоксикации, увеличение сродства гемоглобина к кислороду, сдвиг кислотно-основного состояния крови в сторону алкалоза, развитие окислительного стресса в период отмены этанола при хронической алкоголизации животных.

Keywords

КИСЛОРОДТРАНСПОРТНАЯ ФУНКЦИЯ, КРОВЬ, ПРООКСИДАНТНО-АНТИОКСИДАНТНЫЙ СТАТУС, ЭРИТРОЦИТЫ, АЛКОГОЛЬ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold