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Оценка структурно-функционального статуса митоген-трансформированных лимфоцитов

Оценка структурно-функционального статуса митоген-трансформированных лимфоцитов

Abstract

С использованием методов атомносиловой микроскопии получены новые данные о структуре и свойствах трансформированных лимфоцитов. Показано, что конкановалин А-стимулированные клетки имеют рифленую плазмалемму с преобладанием крупных глобул. Одновременно происходит увеличение жесткости и потенциала их поверхности. Установленные структурно-функциональные особенности пролиферирующих in vitro лимфоцитов могут быть использованы в качестве модели для исследования опухолевого перерождения клеток крови.

The new data on the structure and properties of mitogen-transformed lymphocytes’ was obtained using the methods of atomic-force microscopy. The study demonstrates that Con-A-stimulated cells have grooves in the plasmalemma with the predominance of large globules. Their stiffness and potential surface increase simultaneously. The discovered structural and functional features of proliferating in vitro lymphocytes can be used as a model in the studies of tumor blood cell degeneration.

Keywords

трансформация лимфоцитов; митоген; упруго-эластические свойства; потенциал поверхности; рельеф поверхности, атомно-силовая микроскопия

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average