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Проблема назначения статинов больным с сердечно-сосудистыми заболеваниями и сопутствующими болезнями печени. Что о ней думают практические врачи?

Проблема назначения статинов больным с сердечно-сосудистыми заболеваниями и сопутствующими болезнями печени. Что о ней думают практические врачи?

Abstract

Aim. To study the opinion of doctors about the possibility of statins prescription to patients with cardiovascular diseases and concomitant chronic liver diseases. Material and methods. &oss-sectional questioning of the random sample of physicians was performed. Results. 70 physicians (internists 61.4%, cardiologists 20.0%, neurologists 5.7%, endocrinologists 4.3%, and others) were interviewed. Work experience in the specialty of doctors was 25 years (14; 32.5). 22.9% of doctors completely exclude the possibility of statins prescription to patients with cardiovascular disease if they have concomitant liver disease. 70% of physicians consider it possible to use statin therapy in patients with liver disease, but only under certain conditions. Only a third of them, mostly internists, are ready to prescribe statins under condition of acceptable initial transaminase changes, and almost half of these doctors consider it possible to use statin therapy in patients with concomitant liver diseases only when serum transaminase levels are normal. Conclusion. The physicians often and sometimes unreasonably find it impossible to use statin in patients with cardiovascular diseases and concomitant chronic liver diseases.

Цель. Изучить мнение врачей о возможности и условиях назначения статинов больным с сердечно-сосудистыми заболеваниями (ССЗ) и сопутствующими хроническими заболеваниями печени. Материал и методы. Проведено одномоментное анкетирование случайной выборки врачей. Результаты. Опрошено 70 врачей (терапевты 61,4%, кардиологи 20,0%, неврологи 5,7%, эндокринологи 4,3% и др.), стаж работы по специальности 25 лет (14; 32,5). 22,9% врачей полностью исключают возможность назначения статинов пациентам с ССЗ, если у них выявлены сопутствующие заболевания печени, а 70% считают возможным назначение статинов пациентам с заболеваниями печени, но только при определенных условиях. Из них только треть, преимущественно терапевты, готовы назначить статины при допустимом исходном изменении трансаминаз, а почти половина рассматривает возможность назначения статинов при сопутствующих заболеваниях печени только в случае нормального уровня трансаминаз сыворотки крови. Заключение. Достаточно часто, а в ряде случаев и необоснованно, врачи считают невозможным назначение статинов пациентам с ССЗ с сопутствующими хроническими заболеваниями печени.

Keywords

СТАТИНЫ, НАРУШЕНИЕ ФУНКЦИИ ПЕЧЕНИ, БЕЗОПАСНОСТЬ ТЕРАПИИ, ВЫСОКИЙ РИСК СЕРДЕЧНО-СОСУДИСТЫХ ОСЛОЖНЕНИЙ, ДИСЛИПИДЕМИЯ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold