
In acute experiments on anesthetized cats the antiarrhythmic influence of lidocain and indole derivatives SBT-151 and SBT-818 on neurogenic atrial fibrillation was studied. The comparative appraisal of the results showed the advantage of SBT-151 and SBT-818 in the antiarrhythmic effect duration in comparison with lidocain, which is caused by the longer vagolytic effect of indole derivatives.
В острых опытах на кошках исследовано антиаритмическое влияние лидокаина и производных индола SBT-151 и SBT818 на нейрогенную фибрилляцию предсердий. Сравнительный анализ результатов показал преимущество соединений SBT-151 и SBT-818 в продолжительности антиаритмического эффекта по сравнению с лидокаином, что обусловлено более длительным ваголитическим действием производных индола.
ПРОИЗВОДНЫЕ ИНДОЛА, ЛИДОКАИН, НЕЙРОГЕННАЯ ФИБРИЛЛЯЦИЯ ПРЕДСЕРДИЙ, АНТИАРИТМИЧЕСКОЕ ВЛИЯНИЕ
ПРОИЗВОДНЫЕ ИНДОЛА, ЛИДОКАИН, НЕЙРОГЕННАЯ ФИБРИЛЛЯЦИЯ ПРЕДСЕРДИЙ, АНТИАРИТМИЧЕСКОЕ ВЛИЯНИЕ
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