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Антиагрегационные влияния сосудистой стенки на форменные элементы крови больных артериальной гипертонией с дислипидемией, получающих симвастатин

Антиагрегационные влияния сосудистой стенки на форменные элементы крови больных артериальной гипертонией с дислипидемией, получающих симвастатин

Abstract

The work purpose — to define at patients with an arterial hypertension with a dyslipidemia extent of influence simvastatin on antiaggregatory control from vessels over erythrocytes, platelets and leukocytes. The arterial hypertension registered at patients with a dyslipidemia the strengthened aggregation of erythrocytes, platelets and neutrophils develops against decrease in control over it from the vascular wall, arising in many respects at the expense of violations in a lipidic exchange, activation of oxidation of lipids of plasma and weakening of generation of oxide of nitrogen and education prostacyclin. As a result of 104 week applications simvastatin at patients with an arterial hypertension with a dyslipidemia normalization of lipidic structure, processes of lipid peroxidation in plasma and blood cells and antiaggregatory ability of a vascular wall is reached.

У больных артериальной гипертонией с дислипидемией изучена степень влияния симвастатина на антиагрегационный контроль со стороны сосудов над эритроцитами, тромбоцитами и лейкоцитами. Регистрируемая у больных артериальная гипертония с дислипидемией усиленная агрегация эритроцитов, тромбоцитов и нейтрофилов развивается на фоне снижения контроля над нею со стороны сосудистой стенки, возникающая во многом за счет нарушений в липидном обмене, активации перекисного окисления липидов плазмы и ослабления генерации оксида азота и простациклинобразования. В результате 104 недельного применения симвастатина у больных артериальной гипертонией с дислипидемией достигнута нормализация липидного состава, процессов перекисного окисления липидов в плазме и клетках крови и антиагрегационной способности сосудистой стенки.

Keywords

АРТЕРИАЛЬНАЯ ГИПЕРТОНИЯ, ДИСЛИПИДЕМИЯ, СИМВАСТАТИН, АНТИАГРЕГАЦИОННАЯ АКТИВНОСТЬ СОСУДИСТОЙ СТЕНКИ, ЭРИТРОЦИТЫ, ТРОМБОЦИТЫ, НЕЙТРОФИЛЫ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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