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Маркеры герпетических инфекций при заболеваниях почек у детей

Маркеры герпетических инфекций при заболеваниях почек у детей

Abstract

The aim of the study is to determine the detection frequency of various activity markers of herpetic infections in children with acute and chronic glomerulonephrites, pyelonephrites, tubulointerstitial nephrites. Materials and Methods. There have been examined 180 children with various types of nephrological pathologies: acute and chronic forms of glomerulonephritis, tubulointerstitial nephritis, pyelonephritis. All children have been examined using enzyme multiplied immunoassay to reveal serological markers of herpetic infections, and the majority of children have had their blood and urine tested for human herpes virus by means of polymerase chain reaction. Results. Serological activity markers of herpetic infections were determined more frequently in chronic renal diseases, and particularly frequently in glomerulonephrites, and more rarely-in pyelonephrites. The markers of HSVand EBV-infections are the most common ones. Viral genomes have been revealed mainly in acute forms of renal diseases. A latent cytomegaloviral infection is widespread that is confirmed by cytomegalovirus DNA isolation in urine.

Цель исследования определить частоту выявления различных маркеров активности герпетических инфекций у детей с острыми и хроническими гломерулонефритами, пиелонефритами, тубулоинтерстициальными нефритами. Материалы и методы. Под наблюдением находилось 180 детей с различными видами нефрологической патологии: острые и хронические формы гломерулонефритов, тубулоинтерстициальных нефритов, пиелонефритов. Всем детям проводилось обследование методом ИФА с целью выявления серологических маркеров герпетических инфекций, у большинства детей выполнены анализы крови и мочи методом ПЦР на герпесвирусы. Результаты. Серологические маркеры активности герпетических инфекций определялись чаще при хронических заболеваниях почек, причем наиболее часто при гломерулонефритах и гораздо реже при пиелонефритах. Наиболее распространены маркеры ВПГи ВЭБ-инфекций. Геномы вирусов выявлялись преимущественно при острых формах почечных заболеваний. Широко распространено латентное течение цитомегаловирусной инфекции, которое подтверждено выделением ДНК цитомегаловируса из мочи.

Keywords

ПОЧЕЧНАЯ ПАТОЛОГИЯ, ГЕРПЕТИЧЕСКИЕ ИНФЕКЦИИ, СЕРОЛОГИЧЕСКИЕ МАРКЕРЫ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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