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Пептидергические механизмы регуляции бактерицидной активности альвеолярных макрофагов в условиях эмоционального стресса

Пептидергические механизмы регуляции бактерицидной активности альвеолярных макрофагов в условиях эмоционального стресса

Abstract

In present work the influence of chronic immobilization stress on bactericidal activity of alveolar macrophages after capsaicin application on the neck division of the right vagus nerve and intramuscular administration of leuenkephaline analog dalargine was studied. It was shown that stress is accompanied by the increase of macrophagal bactericidal activity whereas the exhausting of neuropeptides deposit in vagus nerve attenuates this activation. Dalargine caused additional augmentation of bactericidal activity of alveolar macrophages in comparison with stress.

В работе исследовано влияние хронического иммобилизационного стресса на бактерицидную активность альвеолярных макрофагов при односторонней аппликации капсаицина на шейный отдел блуждающего нерва и системном введении аналога лейэнкефалина даларгина. Показано, что стресс сопровождается повышением бактерицидной активности макрофагов. Истощение депо нейропептидов в блуждающем нерве эту активацию устраняет, а даларгин стимулирует дальнейшее увеличение бактерицидной активности макрофагов по сравнению со стрессом.

Keywords

АЛЬВЕОЛЯРНЫЕ МАКРОФАГИ, СТРЕСС, БЛУЖДАЮЩИЙ НЕРВ, КАПСАИЦИН, ДАЛАРГИН

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
bronze