
Проведено изучение психотропной активности новых производных аминоурацила и, в частности, антидепрессивной активности новых производных аминоурацила с использованием наиболее широко применяемых моделей фармакологического скрининга. Наиболее выраженный антидепрессивный эффект на этапе первичного фармакологического скрининга был выявлен у соединения ПИР-03-52 в дозе 10 мг/кг.
Psychotropic effect of the new derivatives of aminouracil models were evaluated using the most common models of the pharmacological screening. The substance with the laboratory code PIR-03-52 in doses of 10 mg/kg demonstrated the most pronounced antidepressant activity effect at the stage of the primary pharmacological screening.
антидепрессивная активность, производные аминоурацила, фармакологический скрининг, крысы.
антидепрессивная активность, производные аминоурацила, фармакологический скрининг, крысы.
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