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Кальпротектин в образцах кала как определитель степень активности воспалительного процесса при воспалительных заболеваниях кишечника

Кальпротектин в образцах кала как определитель степень активности воспалительного процесса при воспалительных заболеваниях кишечника

Abstract

At IBD in the exacerbation phase was detected the increase of fecal calprotectin (FC) level in 98% of patients. With increasing of clinical disease activity in patients with UC as well as CD was marked a significantly increased content of calprotectin in stool samples, which was accompanied by increase of indicators of inflammation acute phase: rising RRF, leukocytosis, an increase of frequency of stool with blood and mucus, fever and abdominal pain. In the phase of exacerbation the increase in concentration of CRP depends on the degree of inflammatory activity, rather than on lesion localization. The highest concentration of CRP was revealed at a high degree of IBD activity with stool frequency up to 8 10 times / day with impurity of blood and abdominal pain. At moderate activity of IBD, it is less expressed diarrhea (stool frequency 2 3 times a day), without blood, detected lower lever of PCF concentration from 250 to 380 ug / g. A study of calprotectin concentrations in stool samples is considered to be reliable and sensitive method for evaluation of inflammatory activity in patients with inflammatory bowel disease.

При ВЗК в фазе обострения увеличение уровня фекального кальпротектина (ФКП) обнаружено у 98% больных. При повышении клинической активности заболевания как у больных ЯК, так и БК отмечалось значимое увеличение содержания кальпротектина в образцах стула, что сопровождалось увеличением показателей острой фазы воспаления: повышением СБР, лейкоцитозом, увеличением частоты стула, с примесью крови и слизи, лихорадкой и болями в животе. В фазе обострения заболевания повышенная концентрация ФКП зависела от степени активности воспалительного процесса, а не от локализации поражения. Наиболее высокая концентрация ПФК выявлялась при высокой степени активности ВЗК при частоте стула до 8 - 10 раз/сут с примесью крови и болях в животе. При умеренной активности ВЗК, менее выраженной диарее (частота стула 2 - 3 раза в день), без примеси крови, выявлялся более низкий уровень ФКП - от 250 до 380 мкг/г. Изучение концентрации кальпротектина в образцах кала считается достоверным и чувствительным методом оценки активности воспалительного процесса у больных воспалительными заболеваниях кишечника

Keywords

БОЛЕЗНЬ КРОНА, CROHN'S DISEASE, ИНФЛИКСИМАБ, МЕЗЕНХИМАЛЬНЫЕ СТРОМАЛЬНЫЕ КЛЕТКИ, ИММУНОСУПРЕССОРЫ, КОРТИКОСТЕРОИДЫ, КАЛЬПРОТЕКТИН В КАЛЕ КРОВИ, ЯЗВЕННЫЙ КОЛИТ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
bronze