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Показатели офтальмотонуса на фоне различных схем местной гипотензивной терапии у больных с первичной открытоугольной глаукомой (многоцентровое исследование)

Показатели офтальмотонуса на фоне различных схем местной гипотензивной терапии у больных с первичной открытоугольной глаукомой (многоцентровое исследование)

Abstract

Objective: to study the intraocular pressure (IOP) in patients with primary open-angle glaucoma during the treatment with hypotensive drugs depending on age, medical history, stage of disease and the central thickness of the cornea. Material and methods. 812 right eyes of 812 patients were examined, 637 of 812 were glaucoma patients and 175 healthy people of the control group. Results. The level of the intraocular pressure was significantly higher in patients with severe glaucoma than in patients with moderate glaucoma or healthy people. There was no significant difference in the central corneal thickness between glaucoma patients and healthy people (both male and female). The IOP level was higher in the group of patients treated with non-fixed combination of beta-blockers and prostaglandins regardless of the disease stage. The IOP compensation was found in 69.9 % of patients with moderate glaucoma and 14.4 % of patients with severe glaucoma. Conclusion. The results of the study can be used as clinical guidelines for determination of the optimal IOP range while choosing the optimal IOP-lowering medications at the start of therapy and during the follow-up of patients with moderate and severe glaucoma.

Цель: определить офтальмотонус у пациентов с первичной открытоугольной глаукомой при лечении разными группами гипотензивных препаратов в зависимости от возраста, анамнеза, стадии заболевания и центральной толщины роговицы. Материал и методы. Обследованы 812 правых глаз 812 человек, из них больных с глаукомой — 637 пациентов, группа контроля — 175 человек. Результаты. Уровень офтальмотонуса у лиц с далеко зашедшей стадией глаукомы был значимо выше, чем у больных с развитой стадией заболевания и у здоровых лиц. Не обнаружено различий в центральной толщине роговицы между здоровыми и больными глаукомой лицами женского и мужского пола. Офтальмотонус был выше в группе, которая получала нефиксированную комбинацию, содержащую бета-адреноблокаторы и простагландины. Компенсация давления была у 69,9 % пациентов с развитой и 14,4 % больных с далеко зашедшей стадиями глаукомы. Заключение. Полученные данные могут быть использованы для клинических рекомендаций по установлению границ офтальмотонуса, а также при выборе оптимальных одного или нескольких препаратов на старте лечения и при динамическом наблюдении за больными с глаукомой.

Keywords

глаукома, внутриглазное давление, центральная толщина роговицы, антиглаукомные препараты

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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