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Патогенетические закономерности поражения центральных отделов глазного дна на фоне периферического увеита

Патогенетические закономерности поражения центральных отделов глазного дна на фоне периферического увеита

Abstract

В эксперименте in vivo установлено, что интравитреальное введение мононуклеаров крови индуцирует развитие витреоретинальной пролиферации. При этом функционально активные мононуклеары крови индуцируют выраженную фиброваскулярную пролиферативную реакцию в полости глазного яблока. Инактивированные мононуклеары вызывают повреждение внутренних слоев сетчатки с образованием эпиретинальной пролиферативной мембраны. При культивировании мононуклеаров крови в условиях направленного движения питательной среды, сходных с движением жидкости в полости глазного яблока, отмечено повышение внутриклеточной ферментативной активности и ускорение процесса дифференцировки моноцитов в макрофаги, а молодых мезенхимальных клеток в зрелые формы.

In experiment in vivo it is established that intravitreal introduction mononuclear blood cells induces development of a vitreoretinal proliferation. Thus functionally active mononuclear cells induce the expressed fibrovascular proliferative reaction in an eyeball cavity. Inactivated mononuclear cells cause damage of inside layers of a retina with formation of an epiretinal proliferative membrane. During cultivation mononuclear blood cells in the conditions of the directed flow of the nutrient medium, similar to liquid movement in an eyeball cavity, increase of endocellular fermentative activity and enhancement of differentiation process of monocytes to macrophage, as well as young mesenchynmal cells in mature forms.

Keywords

МОНОНУКЛЕАРЫ КРОВИ, МИКРООКРУЖЕНИЕ, ХРОНИЧЕСКИЙ ПЕРИФЕРИЧЕСКИЙ УВЕИТ, ВТОРИЧНАЯ МАКУЛОДИСТРОФИЯ, SECONDARY MACULОDYSTROPHY

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
bronze