
New potentiometric sensors based on organic ion exchangers cefixime dimethylstearylammonium sensitive to cefixime were elaborated. Their main electroanalytical characteristics (range of linearity of electrode functions is 1·10-5 1·10-2 M, the slope of electrode functions is 28 ± 2, the concentrations of electrode active compound are 3.11, 3.87%, response time is 60-90 s.; drift of potential is 4.2 mV/day, sensor’s life is 3 months) were determined. The possibility of the sensors application for the cefixime ionometric determination in the phartmaceutical «Supraks» and oral fluid was shown.
Разработаны новые потенциометрические сенсоры на основе органичес ких ионообменников цефиксим диметилдистеариламмоний, чувствительные к цефиксиму. Определены их основные электроанали тические характеристики: интервал линейности электродных функций сос тавляет 1·10.5. 1·10.2 М, угловой коэффициент 28 ± 2, СЭАК = (3,11; 3,87%), время отклика 60-90 с; дрейф потенциала 2-4 мВ/сут; срок службы 3 мес. Показана возможность применения сенсоров для ионометрического оп ределения цефиксима в лекарственном препарате «Супракс» и жидкости ро товой полости.
ЦЕФИКСИМ, РОТОВАЯ ЖИДКОСТЬ, СУСПЕНЗИЯ "СУПРАКС", SUSPENSION "SUPRAKS", СЕНСОРЫ
ЦЕФИКСИМ, РОТОВАЯ ЖИДКОСТЬ, СУСПЕНЗИЯ "СУПРАКС", SUSPENSION "SUPRAKS", СЕНСОРЫ
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