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Сенсоры для контроля содержания цефиксима в ротовой жидкости и суспензии «Супракс»

Сенсоры для контроля содержания цефиксима в ротовой жидкости и суспензии «Супракс»

Abstract

New potentiometric sensors based on organic ion exchangers cefixime dimethylstearylammonium sensitive to cefixime were elaborated. Their main electroanalytical characteristics (range of linearity of electrode functions is 1·10-5 1·10-2 M, the slope of electrode functions is 28 ± 2, the concentrations of electrode active compound are 3.11, 3.87%, response time is 60-90 s.; drift of potential is 4.2 mV/day, sensor’s life is 3 months) were determined. The possibility of the sensors application for the cefixime ionometric determination in the phartmaceutical «Supraks» and oral fluid was shown.

Разработаны новые потенциометрические сенсоры на основе органичес ких ионообменников цефиксим диметилдистеариламмоний, чувствительные к цефиксиму. Определены их основные электроанали тические характеристики: интервал линейности электродных функций сос тавляет 1·10.5. 1·10.2 М, угловой коэффициент 28 ± 2, СЭАК = (3,11; 3,87%), время отклика 60-90 с; дрейф потенциала 2-4 мВ/сут; срок службы 3 мес. Показана возможность применения сенсоров для ионометрического оп ределения цефиксима в лекарственном препарате «Супракс» и жидкости ро товой полости.

Keywords

ЦЕФИКСИМ, РОТОВАЯ ЖИДКОСТЬ, СУСПЕНЗИЯ "СУПРАКС", SUSPENSION "SUPRAKS", СЕНСОРЫ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average