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Изучения фармако-технологических свойств продуктов Sorb-Cel® для создания шипучих таблеток ацетилсалициловой кислоты

Изучения фармако-технологических свойств продуктов Sorb-Cel® для создания шипучих таблеток ацетилсалициловой кислоты

Abstract

В статье предложено использовать новый способ производства шипучих таблеток. Представлено результаты исcледования по разработке шипучих таблеток на основании ацетилсалициловой кислоты с использованием продуктов Sorb-Cel®. Исследовано фармако-технологические свойства трёх типов Sorb-Cel®, а также их изменения при разных соотношениях с ацетилсалициловой кислотой при создании шипучих таблеток. Изучено влияния вспомогательных веществ различного химического строения для получения шипучих таблеток ацетилсалициловой кислоты с Sorb-Cel M или Sorb-Cel R. Установлено изменения фармако-технологических свойств шипучих таблеток ацетилсалициловой кислоты с Sorb-Cel M или Sorb-Cel R при увеличение щелочной фракции, регуляторов кислотности, разрыхлителей, плаздонов, сахаров и смазывающих веществ. На основании выполненных экспериментальных исследований наилучшие значения исследуемых показателей получили при использовании ацетилсалициловой кислоты с Sorb-Cel M и натрия кроскармеллозой в соотношении (1:3:1) при добавлении 1 % натрия лаурилсульфата.The article suggestes to use the new optimal method for production of effervescent tablets. Using of SorbCel® avoiding multiple weighing and mixing of the individual components that accelerate the production of effervescent formulations. Reducing the time of contact with the drug compositions reduce the likelihood of air moisture absorption, which will increase the quality of the final product. It has been represented the research results about the development of effervescent tablets based on acetylsalicylic acid with using products Sorb-Cel®. It has been investigated pharmaco-technological properties of the three types of Sorb-Cel® (Sorb-Cel M, Sorb-Cel R, used in the production of tablets and sachets and Sorb-Cel E for use only in technology sachet), and their changes at different ratios with acetylsalicylic acid for creating effervescent tablets. The survey confirms that Sorb-Cel E is not suitable for the manufacture of effervescent tablets pushing forces on indicators and disintegration time as seasoned trial believe if each of the six tablets disintegrated within 5 minutes. Our studies allows you to select SorbCel M or Sorb-Cel R in comparison with acetylsalicylic acid (3:1) as the most efficient combination. It has been studied of different chemical structure exipients effects on the receipt of effervescent tablets of acetylsalicylic acid with Sorb-Cel M or Sorb-CelR. It has been shown the changes in the pharmaco-technological properties of effervescent tablets, included acetylsalicylic acid, Sorb-Cel M or Sorb-Cel R and alkaline fraction, baking powder, plazdon, sugar and lubricant. On the basis of experimental researches it has been obtained the best value of all the studied parameters, when used acetylsalicylic acid with Sorb-Cel M and sodium croscarmellose in a ratio (1:3:1) with addition 1% sodium lauryl sulfate.

Keywords

ШИПУЧИЕ ТАБЛЕТКИ,SORB-CEL,АЦЕТИЛСАЛИЦИЛОВАЯ КИСЛОТА,ВСПОМОГАТЕЛЬНЫЕ ВЕЩЕСТВА,ФАРМАКО-ТЕХНОЛОГИЧЕСКИЕ СВОЙСТВА,EFFERVESCENT TABLETS,ACETYLSALICYLIC ACID,EXCIPIENTS,PHARMACO-TECHNOLOGICAL PROPERTIES

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average