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Значение оценки критериев недостаточности лютеиновой фазы у пациенток с эндокринными формами бесплодия

Значение оценки критериев недостаточности лютеиновой фазы у пациенток с эндокринными формами бесплодия

Abstract

An Insufficiency of the corpus luteum (LPI) is one of the main causes of endocrine forms of infertility and spontaneous loss of the fetus in early pregnancy. Insufficiency of the corpus luteum, and consequently, defective secretory transformation of the endometrium during the second phase of the menstrual cycle, is a direct consequence of violations of folliculogenesis. A comprehensive assessment of the reproductive system prior to initiating therapy allows to develop algorithm of examination of patients, to choose an individual, pathogenetically substantiated treatment strategy, to select the doses and to avoid the possibility of complications. The object of the study is a comprehensive comparative assessment of the reproductive system of patients with impaired function of the corpus luteum suffering from endocrine forms of infertility and optimization criteria for determining the NLF. Materials and Methods: the study involved 170 women, including the control group. During the study was assessed the state of physical, hormonal profile, as well as ultrasound picture of the state of the reproductive system. Results and Conclusion: LPI is a multifactorial condition. Considering the performance levels of progesterone and estradiol, three forms of insufficient of luteal phase were determined and depending on it, the patients received pathogenetically grounded therapy.

Недостаточность лютеиновой фазы (НЛФ) является одной из основных причин эндокринных форм бесплодия и самопроизвольных потерь плода на ранних сроках беременности. Недостаточность желтого тела и, как следствие, неполноценная секреторная трансформация эндометрия во вторую фазу менструального цикла, является прямым следствием нарушений фолликулогенеза. Комплексная оценка состояния репродуктивной системы до начала терапии позволит выработать алгоритм обследования пациенток, подобрать индивидуальную, патогенетически обоснованную тактику лечения, выбрать дозы препаратов, а также избежать возможность развития осложнений. Цель исследования комплексная сравнительная оценка состояния репродуктивной системы пациенток с нарушением функции желтого тела, страдающих эндокринными формами бесплодия, а также оптимизация критериев определения НЛФ. Материалы и методы в исследовании принимали участие 170 женщин, в том числе и из группы контроля, проводилась оценка соматического состояния, гормонального профиля, а также оценивалась ультразвуковая картина состояния репродуктивной системы. Результаты и заключение. НЛФ является мультифакториальным состоянием. С учетом показателей уровня прогестерона и эстрадиола были определены три формы недостаточности лютеиновой фазы и, в зависимости от этого, пациенты получали патогенетически обоснованную терапию.

Keywords

НЕДОСТАТОЧНОСТЬ ЛЮТЕИНОВОЙ ФАЗЫ,НЛФ,БЕСПЛОДИЕ,РЕПРОДУКТИВНАЯ ЭНДОКРИНОЛОГИЯ,СТИМУЛЯЦИЯ ОВУЛЯЦИИ,LUTEAL PHASE DEFECT,LPD,INFERTILITY,REPRODUCTIVE ENDOCRINOLOGY,STIMULATION OF OVULATION

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    popularity
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average