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Влияние низкодозового импульсно-периодического рентгеновского излучения на рост и метастазирование карциномы легких Льюис

Влияние низкодозового импульсно-периодического рентгеновского излучения на рост и метастазирование карциномы легких Льюис

Abstract

В экспериментах изучалось влияние низкодозового импульсно-периодического рентгеновского излучения (ИПРИ) с импульсами наносекундной длительности на опухолевые клетки карциномы легких Льюис in vitro и in vivo. Установлена зависимость цитостатического и антиметастатического действия ИПРИ от частоты повторения импульсов и мощности импульса. Ингибирование пролиферативной активности опухолевых клеток карциномы легких Льюис in vitro, достигало 30-60 %. Двукратное облучение опухолевого узла ИПРИ с СОД, не превышающей 0,06 Гр, in vivo приводило к торможению роста опухоли лишь на 10-20 %. Максимальное ингибирование процесса метастизирования достигало 16 %.

Influence of low-dose repetitively-pulsed X-ray (RPX-ray) with nanosecond pulse duration on Lewis lung carcinoma in vitro and in vivo was studied. Cytostatic and antimetostatic effects of RPX-ray were found to depend on pulse repetition frequency and dose per pulse. Inhibition of Lewis lung carcinoma in vitro achieved 30-60 %. Two-time irradiation of tumor-bearing mice with the total dose below 0,06 Gy inhibited tumor growth only for 10-20 %. The maximum 16 % of antimetastatic effect after RPX-ray was observed.

Keywords

НИЗКОДОЗОВОЕ ИМПУЛЬСНО-ПЕРИОДИЧЕСКОЕ РЕНТГЕНОВСКОЕ ИЗЛУЧЕНИЕ, КАРЦИНОМА ЛЕГКИХ ЛЬЮИС

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold