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Сквамозная неоплазия глазной поверхности

Сквамозная неоплазия глазной поверхности

Abstract

В статье представлен литературный обзор, посвященный изучению особенностей эпидемиологии, патогенеза, диагностики и лечения сквамозной неоплазии глазной поверхности (СНГП). Частота заболеваемости в различных странах мира значимо варьирует от 0,03 до 3,5 случаев на 100 000 населения. Наиболее значимыми и изученными причинами развития новообразований глазной поверхности являются солнечная инсоляция, вирус папилломы человека, вирус иммунодефицита человека. Вариабельность клинической картины требует правильной дифференциальной диагностики, так как течение СНГП часто маскируется под дистрофические заболевания конъюнктивы (пингвекула, птеригиум), васкуляризованные помутнения роговицы, а так же может проявлять себя как меланома или невус. Трудности дифференциальной диагностики с учетом данных клинического осмотра обуславливают необходимость применения высокотехнологичных методов исследования (оптическая когерентная томография переднего отрезка глаза) и обязательной морфологической диагностики (цитологическая и гистологическая диагностика). Лечение СНГП включает различные терапевтические и хирургические подходы, а чаще их комбинацию хирургическое удаление новообразования и применение цитостатиков или препаратов интерферона, однако не учитывает этиологию заболевания. Частота рецидива СНГП остается по-прежнему высокой от 10 до 56% случаев в зависимости от характера роста, объема хирургического вмешательства и продолжительности послеоперационного ведения пациентов. Представляется актуальным дальнейшее изучение этиологии и патогенеза сквамозной неоплазии глазной поверхности, а так же разработка комплексных подходов в диагностике и лечении с учетом этиологии заболевания.

The article presents a scientific literature review devoted to studying the features of epidemiology, pathogenesis, diagnosis and treatment of ocular surface squamous neoplasia (OSSN). In different countries morbidity rate varies significantly from 0,03 to 3,5 cases per 100 000 population. The most important and studied causes of ocular surface neoplasia development are considered to be solar insolation, human papilloma virus, human immunodeficiency virus. Variability of the clinical picture requires the proper differential diagnostics, since OSSN often masks as degenerative diseases of the conjunctiva (pinguecula, pterygium), vascularized corneal opacity, and can also manifest itself as melanoma or nevus. Difficulties in the differential diagnostics based on clinical examination data necessitate the usage of high-tech research methods (optical coherence tomography of the ocular anterior segment) and the obligatory morphological diagnostics (cytological and histological diagnosis). Treatment of OSSN includes various medical and surgical approaches, more often their combination surgical removal of tumors or usage of cytostatics or the medication interferon without taking into consideration the etiology. The high recurrence rate of OSSN is still remained 10-56% of cases depending on the growth type, volume of surgery and duration of postoperative care of patients. It is relevant to further studying the etiology and pathogenesis of ocular surface squamous neoplasia, as well as the development of integrated approaches in diagnosis and treatment taking into account the etiology of disease.

Keywords

РОГОВИЦА,CORNEA,КОНЪЮНКТИВА,CONJUNCTIVA,ГЛАЗНАЯ ПОВЕРХНОСТЬ,OCULAR SURFACE,СКВАМОЗНАЯ НЕОПЛАЗИЯ,SQUAMOUS NEOPLASIA,НОВООБРАЗОВАНИЕ,NEOPLASM,ЧАСТОТА ЗАБОЛЕВАЕМОСТИ,ЭТИОЛОГИЯ ЗАБОЛЕВАНИЯ,ETIOLOGY OF THE DISEASE,MORBIDITY RATE

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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