Аномалии кариотипа при хронических миелопролиферативных неоплазиях
Copyright policy )Аномалии кариотипа при хронических миелопролиферативных неоплазиях
Frequency of occurrence of the JAK2V617F mutation for patients with different variants of Tronic myeloproliferative disorders (CMPD) is observed. Assessment in order to get differentional diagnostics of CMPD with nonproliferative diseases of the blood was evaluated in 79 cases of 128 (that is 61.7%). The cytogenetical research showed that 2 patients of 20 (10%) have clonal chromosome aberrations with poor prognosis.
C целью дифференциальной диагностики хронических миелопролиферативных заболеваний (ХМПЗ) с другими заболеваниями системы крови проведено исследование мутации JAK2V617F и цитогенетическое исследование. Мутация JAK2V617F выявлялась у 79 больных из 128, что составляет 61,7%. При цитогенетическом исследовании у 2 (10%) из 20 больных были обнаружены клональные прогностически неблагоприятные хромосомные аберрации.
ХРОНИЧЕСКОЕ МИЕЛОПРОЛИФЕРАТИВНОЕ ЗАБОЛЕВАНИЕ, JAK2V617F МУТАЦИЯ, ХРОМОСОМНЫЕ АБЕРРАЦИИ
ХРОНИЧЕСКОЕ МИЕЛОПРОЛИФЕРАТИВНОЕ ЗАБОЛЕВАНИЕ, JAK2V617F МУТАЦИЯ, ХРОМОСОМНЫЕ АБЕРРАЦИИ
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