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Возможности прогнозирования рецидива рака простаты после HIFU-аблации с помощью математического моделирования

Возможности прогнозирования рецидива рака простаты после HIFU-аблации с помощью математического моделирования

Abstract

HIFU-аблации простаты достаточно высока.Research objective: Creation of mathematical prognosis of model of local relapsing tumors in patients with prostate cancer after treatment by high-intensive focused ultrasound (HIFU). Objects and Research Methods: Results of treatment are estimated at 102 patients with morphologically localized prostate cancer proved at biopsy. For the purpose to analyze interrelation of prognostic factors and postoperative morphological research of prostate control biopsies after HIFU ablation with frequent development of relapses comparative statistical research of received data has been conducted. For construction of mathematical models of relapse prognosis after HIFU of prostates two methods of mul-tifactorial analysis of the data have been used: the discriminant analysis and logistical regress. Results: While planning treatment of patients after HIFU ablation of prostates it has been necessary to estimate morphological risk factors of local relapse of a neoplasm such as preoperative level of serum PSA, the sum of Gleason, severity of disease, presence of lymphovascular and perineural invasion. The offered formulas are worth while using in revealing of probability of development of relapses. The comparative analysis of mathematical models has showed that accuracy of prognosis of results of HIFU of prostates is high enough.

Цель; создание математической модели прогноза местного рецидивирования опухоли у больных раком простаты после лечения высокоинтенсивным сфокусированным ультразвуком (HIFU). Материал и методы. Результаты лечения оценены у 102 пациентов с морфологически доказанным при биопсии локализованным раком простаты (РП). С целью анализа взаимосвязи прогностических факторов, послеоперационного морфологического исследования контрольных биоптатов простаты после HIFU-аблации с частотой развития рецидива заболевания проведено сравнительное статистическое исследование полученных данных. Для построения математических моделей прогноза-рецидива после HIFU-аблации простаты использовались два метода многофакторного анализа данных: дискриминантный анализ и логистическая регрессия. Результаты. При планировании лечения пациентов после HIFU-аблации простаты необходима комплексная оценка морфологических факторов риска местного рецидива новообразования, таких, как предоперационный уровень сывороточного PSA, сумма Глисона, стадия заболевания, наличие лимфоваскулярной и периневральной инвазии. Выявление вероятности развития рецидива целесообразно проводить с помощью предложенных нами формул. Заключение. При сравнительном анализе созданных нами математических моделей выявлено, что точность прогноза результатов

Keywords

ВЫСОКОИНТЕНСИВНЫЙ СФОКУСИРОВАННЫЙ УЛЬТРАЗВУК (HIFU), МАТЕМАТИЧЕСКОЕ МОДЕЛИРОВАНИЕ, ПРОГНОСТИЧЕСКИЕ ФАКТОРЫ, ПРОСТАТОСПЕЦИФИЧЕСКИЙ АНТИГЕН (PSA), РАК ПРОСТАТЫ, УЛЬТРАЗВУКОВАЯ ХИРУРГИЯ, HIGH INTENSITY FOCUSED ULTRASOUND (HIFU)

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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