Throughout the period of administration of the test drug in female rats no signs of toxicity, mortality and apparent disturbances of pregnancy. Dynamic observation for growth of body weight in females experienced no reduction at all weight gain was recorded as compared to control animals. Death of embryos at all stages of development from tested female rats did not differ from control values. Study of embryonic material suggests that the indices in the experimental animals did not differ significantly from those in the controls. This indicates that administration of ivermectin to rats at different stages of pregnancy, including critical periods in the therapeutic dose of 0,2 mg/kg has no embryotoxicity or teratogenicity.

Введение. По данным литературных источников ивермектин в терапевтической дозе 0,2 мг/кг не проявляет эмбриотропного действия [10]. K.S. Khera (1984) и R.L. Brent (1986) при изучении эмбриотропных свойств ивермектина на мышах установили отрицательное влияние препарата в дозе 0,4 мг/кг. У плодов опытных мышей они регистрировали проявление мутаций («волчья пасть»). На крысах нарушения эмбриогенеза наблюдали в дозе 10 мг/кг. Уродства у эмбрионов кроликов отмечали в дозе 3 мг/кг [9,12].