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Интенсивность сосудистого воспаления у пациентов с артериальной гипертензией на фоне проводимой терапии

Интенсивность сосудистого воспаления у пациентов с артериальной гипертензией на фоне проводимой терапии

Abstract

The objective of research is to carry out comparative studying of levels of markers of vascular inflammation in blood serum at patients with arterial hypertension against hypotensive therapy. Materials and methods. 120 men (middle age was 33,4 ± 2,9 years) with verified diagnosis of arterial hypertension receiving standard anti-hypertensive therapy (losartan) are examined. The following data was defined in blood serum: concentration of glucose and fractions of cholesterol (TG, HDL, VLDL, LDL), endothelin-1, homocysteine and chCRP. Results. The more HC high levels and chCRP in blood serum at patients with unachieved AH level in comparison with group of patients at whom the AH level against hypotensive therapy reached target values are registered. Conclusion. The received results testify to associativity of intensity of vascular inflammation and efficiency of hypotensive therapy.

Цель исследования. Провести сравнительное изучение уровней маркеров сосудистого воспаления в сыворотке крови у пациентов с артериальной гипертензией на фоне гипотензивной терапии. Материалы и методы. Обследовано 120 мужчин (средний возраст 33,4 ± 2,9 года) с верифицированным диагнозом артериальной гипертензии, получавших стандартную антигипертензивную терапию (лозартан). Определяли в сыворотке крови: концентрацию глюкозы и фракций холестерина (ТГ, ЛПВП, ЛПОНП, ЛПНП), эндотелина-1, гомоцистеина и вчСРБ. Результаты. Выявлены достоверно более высокие уровни ГЦ и вчСРБ в сыворотке крови у пациентов с недостигнутыми уровнем АД по сравнению с группой пациентов, у которых уровень АД на фоне гипотензивной терапии достиг целевых значений. Заключение. Полученные нами результаты свидетельствуют о сопряженности интенсивности сосудистого воспаления и эффективности гипотензивной терапии.

Keywords

АРТЕРИАЛЬНАЯ ГИПЕРТЕНЗИЯ, СОСУДИСТОЕ ВОСПАЛЕНИЕ, ЭНДОТЕЛИН-1, ГОМОЦИСТЕИН, ВЧСРБ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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