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Суточное мониторирование показателей артериальной ригидности при оценке эффективности антигипертензивной терапии

Суточное мониторирование показателей артериальной ригидности при оценке эффективности антигипертензивной терапии

Abstract

Цель исследования определить возможности суточного мониторирования показателей артериальной ригидности при оценке эффективности антигипертензивной терапии (АГТ). Материалы и методы. Было проведено открытое, перекрестное рандомизированное исследование эналаприла (Э) в дозах 5-20 мг и метопролола (М) в дозах 100-200 мг в сутки у 32 больных со стабильной артериальной гипертонией (средний возраст 55,0 ± 0,2 года), подтвержденной результатами суточного мониторирования артериального давления (АД). Мониторирование АД и показателей артериальной ригидности прибором BPLab МнСДП-3 проводилось 4 раза: исходно, в конце курса лечения каждым из препаратов, а также в период отмены АГТ между курсами. Изучались следующие параметры: время распространения пульсовой волны (первый способ, отражающий ригидность плечевой артерии PTT1; второй способ, отражающий параметры ригидности в аорте PTT2), индекс аугментации (AIX), индекс ригидности артерий (ASI), максимальная скорость нарастания АД ([dP/dt]max). Результаты. Оба препарата вызывали выраженное снижение 24-часового систолического/диастолического АД: на 20,5 ± 1,6/11,6 ± 1,3 мм рт. ст. на фоне М и на 18,4 ± 1,6/12,3 ± 1,2 мм рт. ст. на фоне Э (p

Objective. To assess the possibilities of 24-hour arterial stiffness monitoring in evaluation of antihypertensive treatment efficacy. Design and methods. We performed an open, cross-sectional, randomized trial in 32 patients with stable arterial hypertension (mean age 55 ± 0,2 years) treated consequently by enalapril (E) 5-20 mg/day and metoprolol (M) 100-200 mg/day. 24-hour blood pressure and arterial stiffness monitoring (BPLab) was performed 4 times: initially, at the end of treating by each of the drugs and in «wash-out» periods between different treatment. The following parameters were assessed: pulse wave velocity (2 ways of evaluation PTT1 and PTT2); augmentation index (AIX), arterial stiffness index (ASI), maximal blood pressure gradient ([dP/dt]max). Results. Both drugs had an antihypertensive effect (20,5 ± 1,6/11,6 ± 1,3 mmHg at M treatment and -18,4 ± 1,6/12,3 ± 1,2 mmHg at E therapy, p

Keywords

АРТЕРИАЛЬНАЯ РИГИДНОСТЬ, СКОРОСТЬ РАСПРОСТРАНЕНИЯ ПУЛЬСОВОЙ ВОЛНЫ, ОСЦИЛЛОМЕТРИЧЕСКИЙ МЕТОД, СУТОЧНОЕ МОНИТОРИРОВАНИЕ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
gold