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Исследование влияния мексикора на антиаритмическую активность аллапинина при сочетанных нарушениях ритма сердца

Исследование влияния мексикора на антиаритмическую активность аллапинина при сочетанных нарушениях ритма сердца

Abstract

Представлены результаты исследования комбинированного применения антиаритмического препарата «Аллапинин» и цитопротектора мексикора. Обследовано 60 больных с различными нарушениями ритма сердца (средний возраст 51,6 ± 1,9 года). Первой группе (n = 30) назначали мексикор (300 мг/сут внутривенно капельно на 200 мл изотонического раствора хлорида натрия) и аллапинин (37,5–75 мг/сут per os), второй группе (n = 30) – аллапинин (37,5–75 мг/сут per os) на фоне базисной терапии основного заболевания. Показано, что включение в терапию мексикора привело к более выраженному антиаритмическому эффекту как в отношении наджелудочковой, так и желудочковой эктопической активности по сравнению с монотерапией аллапинином. На фоне комбинированной терапии аллапинином и мексикором выявлено улучшение систолической функции левого желудочка и не зафиксировано патологических изменений параметров ЭКГ.

Results of research of the combined application antiarrhythmic drag allapinin and a cytoprotector mexicor are presented. 60 patients with various infringements of a rhythm of heart (average age 51,6 ± 1,9 year). To the first group(n = 30) appointed mexicor (300 mg/sut intravenously to 200 ml of an isotonic solution of chloride of sodium) and allapinin (37,5–75 mg/sut per os), the second group (n = 30)– allapinin (37,5–75 mg/sut per os) against basic therapy of the basic disease. It is shown that inclusion in therapy mexicor has led more expressed antiarrhythmic effect in comparison with monotherapy allapinin that was shown as in the relation supraventricular and ventricular arrhythmia.

Keywords

НАРУШЕНИЯ РИТМА СЕРДЦА, ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА, АЛЛАПИНИН, МЕКСИКОР

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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