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Индекс висцерального жира у больных акромегалией: клинические, гормонально-биохимические корреляции

Индекс висцерального жира у больных акромегалией: клинические, гормонально-биохимические корреляции

Abstract

Показано, что индекс висцерального жира (ИВЖ) у больных акромегалией (n=88) коррелирует с уровнем соматотропного гормона гипофиза (СТГ) (r s=0,31, р=0,005) и клинически экспрессируется снижением чувствительности тканей к инсулин-опосредованному усвоению глюкозы, ухудшением постпрандиального усвоения глюкозы, повышением резистентности к инсулину на фоне неадекватной продукции инсулина, гиперлептинемией, повышением атерогенного потенциала плазмы. Больные акромегалией с высоким ИВЖ имеют более высокий кардиоваскулярный риск по сравнению с нормальным ИВЖ. Предикторами увеличения ИВЖ у больных акромегалией есть уровень СТГ (t=4,55, p=0,00001) и глюкозы натощак (t=7,57, p=0,00001) в крови.

Shows that the of visceral adiposity index (VAI) in patients with acromegaly (n = 88) correlates with the level of growth hormone (GH) (r s=0.31, p=0.005) and clinically expressed decreased the sensitivity of tissues to insulin-glucose absorption, postprandial decrease in glucose disposition, increasing insulin resistance, inadequate production of insulin, high level of leptin, increased atherogenic potential of plasma. Patients with acromegaly with high AVI have higher cardiovascular risk compared to normal AVI. Predictors of increased AVI in patients with acromegaly is the level of GH (t=4.55, p=0.00001) and fasting glucose (t=7.57, p=0.00001).

Keywords

АКРОМЕГАЛИЯ, СОМАТОТРОПНЫЙ ГОРМОН ГИПОФИЗА, ВИСЦЕРАЛЬНАЯ ЖИРОВАЯ ТКАНЬ, ИНДЕКС ВИСЦЕРАЛЬНОГО ЖИРА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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