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Гидроксилазный путь обмена L-триптофана в головном мозге крыс: острые эффекты lтриптофана, этаноламина, вальпроевой кислоты и двух аминокислотных композиций в темновую фазу обращенного светового цикла

Гидроксилазный путь обмена L-триптофана в головном мозге крыс: острые эффекты lтриптофана, этаноламина, вальпроевой кислоты и двух аминокислотных композиций в темновую фазу обращенного светового цикла

Abstract

Смесь аминокислот с разветвленной углеводородной цепью (АРУЦ), таурина и триптофана (600 мг/кг) повы­шает оборот серотонина в гипоталамусе, стриатуме и больших полушариях мозга крыс в условиях обращенного светового цикла в равной степени, как и L-триптофан (100 мг/кг), но в меньшей мере повышает содержание триптофана и его минорных метаболитов. Вальпроевая кислота (400 мг/кг) и этаноламин (100 мг/кг) ингибируют N-ацетилтрансферазный путь в гипоталамусе, эпифизе и среднем мозге.

The mixture of branched-chain amino acids (BCAA), taurine and tryptophan (600 mg/kg) enhanced turnover of serotonin in hypothalamus, striatum and brain hemispheres of rats under reversed photocycle in the same extent as L-tryptophan (100 mg/kg), with less pronounced increase of the levels of tryptophan and its minor metabolites. Valproic acid (400 mg/kg) and EA (100 mg/kg) inhibited N-acetyltransferase pathway in hypothalamus, pineal gland and midbrain.

Keywords

МЕТАБОЛИЗМ ТРИПТОФАНА, L-АМИНОКИСЛОТЫ, ЭТАНОЛАМИН, ВАЛЬПРОЕВАЯ КИСЛОТА, ЦИРКАДИАННЫЙ РИТМ, МОЗГ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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