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Зміни характеру взаємовідношень клінічних та імунологічних показників у дітей, хворих на поліноз, під впливом алерген-специфічної імунотерапії

Зміни характеру взаємовідношень клінічних та імунологічних показників у дітей, хворих на поліноз, під впливом алерген-специфічної імунотерапії

Abstract

IL-4, IL-5, IL-10 и их основным антагонистом IL-12 под влиянием АСИТ как в виде подкожных инъекций, так и в виде пероральных сублингвальных драже.In the article dynamics of clinical symptomatics in children aged from 6 to 18 years, suffering from pollinosis using subcutaneous and peroral methods of allergen-specific immunotherapy (ASIT) and standard therapy (ST) with pharmacological medicines is analyzed. There has been shown the efficacy of the treatment-efficiency questionnaires for the ill children and their parents, proposed in the study. The positive effect of both ASIT methods on the state of clinical indicators has been shown both for the monthly exacerbation (August, September, October) and the season of cause-significant plants pollination in general. There has been revealed the increase of correlation relationships between markers of allergic inflammation of pollinosis interleukines IL-4, IL-5, IL-10 and their main antagonist IL-12 under the influence of ASIT both in the method of subcutaneous injections and peroral sublingual dragees.

В статье проанализирована динамика показателей клинической симптоматики у детей в возрасте от 6 до 18 лет, больных поллинозом, при использовании подкожного и перорального методов аллерген-специфической иммунотерапии (АСИТ) и стандартной терапии (СТ) фармакологическими преапаратами. Установлена эффективность предложенных в исследовании анкет оценки эффективности лечения для больных детей и их родителей. Показано положительное влияние обоих методов АСИТ на состояние клинических показателей как по отдельным месяцам обострения (август, сентябрь, октябрь), так и за сезон поллинации причиннозначимых растений в целом. Выявлено усиление корреляционных взаимосвязей между маркерами аллергического воспаления при поллинозе – интерлейкинами

Keywords

ПОЛіНОЗ У ДіТЕЙ, АЛЕРГЕН-СПЕЦИФіЧНА іМУНОТЕРАПіЯ, КЛіНіЧНі ПОКАЗНИКИ, іМУНОЛОГіЧНі ПОКАЗНИКИ, КОРЕЛЯЦіЯ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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