A leading factor in urolithiasis is intoxication syndrome developing in the course of an integral process. Of primary importance is evaluation of renal dysfunction and severity of endotoxicosis by X-ray, morphological, ultrasound, and hemodymamic studies for differential preoperative diagnostics. The aim of this work was to assess the degree of endogenous intoxication (EI) in children with urolithiasis for the choice of methods for the correction ofpathological changes. Materials and methods. The study included 187 children aged 6 momths 15 years. Single and multiple calculi occurred in 126 (67.4%) and 61 (32.6%) patients respectively. Five (2.67°%) children had calculi in both kidneys and ureters, six (3.2%) in a kidney and an ureter, 13 (6.95%) in a kidney, ureter and urinary bladder. Objective evaluation of severity of the patients’ condition was performed by general clinical observation, laboratory, ultrasound amd X-ray studies. EI and effectiveness of intensive therapy were estimated from the levels of medium molecular weight peptides in peripheral blood (measured by the Gabrieliyan method, 1983), paramecium lifetime, Kalf-Kalif’s leukocyte intoxication index, glomerular filtration rate, and tubular reabsorption. Results. All patients presented with chronic calculous pyelonephritis. Results of evaluation of EI were used to develop methods for differential preoperative preparation of children with urolithiasis. Conclusion. The study of EI in patients with urolithiasis implies the necessity of individual choice of the character of preoperative preparation. The renoprotective strategy should be built up on the principles of early detection of intoxication, its adequate diagnostics and rational treatment taking account of the severity of inflammation. Differential preoperative care may promote the improvement of prognosis of the disease and the patients ’ quality of life.

Целью исследования была оценка степени эндогенной интоксикации (ЭИ) у детей с уролитиазом для определения способов ее коррекции. У 187 детей с мочекаменной болезнью в возрасте от 6 мес до 15 лет всесторонне исследовали ЭИ. Одиночные камни были у 126 (67,4%) детей, а множественные у 61 (32,6%) ребенка. Для объективной оценки тяжести состояния детей с мочекаменной болезнью, кроме общеклинических данных, изучали клинико-лабораторные, рентгенологические показатели, а также результаты УЗИ почек и мочевых путей. Определяли уровень среднемолекулярных пептидов (СМП) в периферической крови по Габриэлян (1983), продолжительность жизни парамеций (ПЖП), лейкоцитарный индекс интоксикации (ЛИИ) по Кальф-Калифу, клубочковой фильтрации и канальцевой реабсорбции. У всех больных наблюдался хронический калькулезный пиелонефрит. На основании оценки степени ЭИ разработаны дифференцированные способы предоперационной подготовки детей с уролитиазом.