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Трофобластические опухоли: к вопросу о классификации и факторах прогноза (часть II)

Трофобластические опухоли: к вопросу о классификации и факторах прогноза (часть II)

Abstract

Изучение факторов, влияющих на прогноз злокачественных трофобластических опухолей, позволит адекватно планировать лечение. Гистологическая форма трофобластической опухоли имеет важное прогностическое значение. Так, худшим прогнозом характеризуются хориокарцинома и эпителиоидная опухоли, трудно предсказуем прогноз для трофобластической опухоли плацентарного ложа и наиболее благоприятным ожидается прогноз при инвазивном и метастатическом пузырных заносах. Важными факторами прогноза являются возраст пациентки, исход предшествующей заболеванию беременности, длительность анамнеза, исходный уровень β-хорионического гонадотропина, размеры первичной опухоли, локализация, размеры и количество метастазов. Неадекватная химиотерапия, предшествующая стандартному лечению, способствует возникновению лекарственной резистентности опухоли и значительно ухудшает прогноз. Современная классификация FIGO, 2000 г., включает клиническое стадирование и шкалу факторов прогноза, на основании которой планируется стандартная химиотерапия трофобластичских опухолей.

Study of factors affecting the prognosis of malignant trophoblastic tumors, allow adequate treatment plan. Histological form trophoblastic tumor has important prognostic value. Chorionic carcionoma and epithelioid tumors are characterized by a worse prognosis, it is difficult to predict the prognosis for placental trophoblastic tumor and the most favorable prognosis is expected in the invasive and metastatic hydatidiform mole. Important prognostic factors are the age of the patient, the outcome of the previous pregnancy disease, length of history, the initial level of beta-human chorionic gonadotropin tumor size, location, size and number of metastases. Inadequate chemotherapy prior to standard treatment, contributes to the emergence of drug resistance of tumors and significantly worsens the prognosis. Modern FIGO classification 2000, includes clinical staging scale and prognostic factors based on which you plan to standard chemotherapy trophoblastic tumors.

Keywords

ЗЛОКАЧЕСТВЕННАЯ ТРОФОБЛАСТИЧЕСКАЯ ОПУХОЛЬ, ХОРИОКАРЦИНОМА, СТАНДАРТНАЯ ХИМИОТЕРАПИЯ, ФАКТОРЫ ПРОГНОЗА, ПЛАНИРОВАНИЕ ЛЕЧЕНИЯ, КЛАССИФИКАЦИЯ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Average
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