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Нерешённые вопросы лечения деформирующей остеодистрофии (болезнь Педжета)

Нерешённые вопросы лечения деформирующей остеодистрофии (болезнь Педжета)

Abstract

Paget disease in clinical practice is rare. By its nature the disease represents the disorder of bone remodeling processes. The etiology still has been studied insufficiently. We have generalized the experience of treatment of 33 patients. The most frequent localization of the process is noted in femur and tibia. Clinical picture manifests itself as pain, limb deformity, as well as malignization is possible. The diagnosis is based on the data of roentgenography, CT, MSCT, MRT. Treatment with bisphosphonates (fosamax) and thyrocalcitonin is effective, but prolonged. Surgical treatment is performed if indicated: osteosynthesis, endoprosthetics, amputations.

Болезнь Педжета в клинической практике встречается не часто. Сущность ее сводится к нарушению процессов ремоделирования кости. Этиология остается недостаточно изученной. Нами обобщен опыт лечения 33 больных. Наиболее частая локализация процесса в бедренной и большеберцовой костях. Клиника проявляется болями, деформацией конечности, возможна малигнизация. Диагноз основывается на данных рентгенографии, КТ, МСКТ, МРТ. Лечение бисфосфонатами (фосамакс) и тирокальцитонином эффективное, но длительное. По показаниям выполняется оперативное лечение: остеосинтез, эндопротезирование, ампутации.

Keywords

БОЛЕЗНЬ ПЕДЖЕТА, КОНСЕРВАТИВНОЕ И ОПЕРАТИВНОЕ ЛЕЧЕНИЕ

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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