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Биофизическая структура внешнего слоя плазматической мембраны опухолевых клеток (гликокаликса)

Биофизическая структура внешнего слоя плазматической мембраны опухолевых клеток (гликокаликса)

Abstract

В статье рассматривается структура внешнего слоя плазматической мембраны клетки (гликокаликса), состоящей из гликозаминогликанов. Экспериментально обнаружено, что в концентрированном растворе электролита 15% (2,6 М) растворе хлорида натрия в течение 2 с гликокаликс набухает или увеличивается в размере с 4 до 20 000 нм. Набухший гликокаликс имеет периодическую сетчатую структуру с периодом в 100 -150 нм. Первичной единицей набухшего гликокаликса является квант гликокаликса, или образование шарообразной формы размером примерно 100 нм. Вне концентрированного раствора электролита размер кванта гликокаликса не превышает 10 нм.

The paper describes structure of tumor cell plasmatic membrane upper layer (glycocalix) consisting of glycosaminoglycans. As discovered experimentally, glycocalyx swells or expands from 4 to 20,000 nm at 2 s in concentrated electrolyte (15% [2.6 M] sodium chloride) solution. The swollen glycocalyx has a periodical net structure with a period of 100-150 nm. A quant of glycocalyx or a spheroid of about 100 nm in size is the primary unit of the swollen glycocalyx. Outside the concentrated electrolyte solution a quant of glycocalyx is not more than 10 nm.

Keywords

ОПУХОЛЕВАЯ КЛЕТКА, ПЛАЗМАТИЧЕСКАЯ МЕМБРАНА, ГЛИКОКАЛИКС, КВАНТ ГЛИКОКАЛИКСА

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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