This study examines the application of game theory in strategic supplier negotiations within procurement to achieve win-win outcomes. Using a mixed-methods approach, the research integrates quantitative statistical modeling, including chi-square tests (χ² = 8.57, p < 0.05), regression analysis (R² = 0.94), and t-tests (t = 8.49, p < 0.01), with qualitative insights from industry experts. The findings indicate that applying game-theoretic models enhances negotiation efficiency, yielding an increase in cost savings from 12.5% in 2020 to 22.1% in 2024 and improving supplier satisfaction levels from 70% to 87%. The study further reveals a strong correlation (r = 0.92, p < 0.01) between game theory adoption and procurement performance, demonstrating its effectiveness in fostering long-term supplier relationships. Key recommendations include integrating AI-driven analytics to mitigate information asymmetry, adopting multi-round negotiation strategies, and establishing cooperative supplier relationship frameworks. These insights provide a structured foundation for procurement professionals seeking to optimize decision-making and negotiation strategies in dynamic market environments.