The plant Kalanchoe pinnata (Lam.) Pers. contains primary and secondary metabolites. Therefore, they are utilized in medications to treat and prevent different illnesses. The studies done on the plant Kalanchoe pinnata exhibit a variety of biological activities. The plant’s parts consist of various phytochemicals that possess therapeutic activities. The plant Kalanchoe pinnata is found in various parts of the world mainly in tropical and sub-tropical regions and used in medication of various diseases like kidney stones, urinary tract disorders, skin wounds and respiratory ailments. The parts of the whole plant are used as the therapeutic such as leaves, stem, roots. It affects gastrointestinal function, hypertension, diabetes, inflammation, and arthritis. The several phyto-constituents present in the plant are glycosides, amino acids, flavonoids, alkaloids, saponin, terpenoids etc. In this article, various biological activities of Kalanchoe pinnata plant extracts are summarized. This literature review is prepared by using articles obtained from pharmaceutical journals and internet sources such as science direct , NCBI, elsevier journal, google scholar and research articles from which information is collected such as Kalanchoe pinnata, metabolites, activities, pharmacological and phytochemical value will be collected approximately 620 compounds from this genus have been isolated and used in the treatment of different diseases.