The understanding of memory and sleep has greatly deepened in the past century and continues developing until today. The most recent advances in this field of research have allowed the invention of methods for manipulating memory consolidation by sensory stimulation during sleep. Acoustic stimulation especially gained popularity. It seems to offer not only a great opportunity for better understanding of the interplay between sleep and memory consolidation, but also a possibility for use in the therapy of neurodegenerative diseases and many more. Despite the papers already published on this topic, none has focused on the influence of closed-loop targeted memory reactivation on episodic memory as described by its three components of what-where-when. Furthermore, there remains a knowledge gap on how this intervention influences direct measures of episodic memory consolidation in sleep, such as slow oscillations and sleep spindles. Therefore, this study aimed to cover these questions. We tested episodic memory components in a 3D virtual environment where participants had to remember specific objects, where and in what order they collected them. Sleep parameters of memory consolidation were measured by polysomnography during full night sleep, with or without acoustic stimulation. The findings obtained...