????????: ?????????????????? ???????????????????????? ???????????????????? ???? ???????????????????????? ?????????????????????????????? ???????????? ???????????????????? ?????????????????????????????????? ???????????????? (????) ?? ?????????????????? ?????????? ?????????????????? ???????????????? ???????? ?? ???????????????????????????????????? ???????????????????? ?????? ???????????????? ?????????????????? ???? ?????????????????????? ???????????????????????? ?????????????????? ?????????????????????? ???????????????????????? (????). ????????????? ?? ????????????: ???????????????????? ???????????? ?????????????????? ?????????? 144 ?????????????????????????????????????????? ?????????????????? ???????????????? ????????, ?? ???????? 90% ?????????????????? ?????????? ???? ???????????????????????????????????? ????????????????????. ?????? ???????????????? ?????????????? ?????????????????? ???????????????????????? ?????????????????????????? ????????????????????, ?????? ???????????????? ?????????????????????????????? ???????????? ???? ??????????????????????? ???????????????????????? ??????????????????????, ???????????????????? ???? ?????????????????? ????. ???????????????????? ???? Aspergillus ?? ?????????????????? ???????????????????????? ?????????? ?????????????????? ?????????????????????????????? ?????????????? ?? ?????????????????????????? ????????-?????????????? ??Platelia Aspergillus Ag?? ?????????????????????? ??Bio-Rad?? 1 ?????? ???? ?????????????? ???????????????? ???????????? ?????????????? ?????????????????????? ?? ????????????????????, ?? ?????????? ???????????????? ?????????? ???????????????????????????? ??????????????. ????????????????????: ???? ?? ?????????????????? ?????????? ???????????????? ?? 7 ???? 144 ???????????????????? ??????????????????. ?????????????? ???? ?? ???????????? ???? ?????????????? ?? ?????????????????? ?????????? ???? ???????????????????????? ???????????????????????? ????????????????????????? ???????????????????? ?? 85,7% ????????????????. ???????????????????????????? ???????????????????? ?????????????????????? ?? ???????????????????? ?????????? ?????????????????? ???????? ????????????????. ?????????????????? ?????????????????????????????? ?????????????????????? ?????????????????? 3%. ???????????? ?? ???????????? ?????????????????????????????? ?????????????????????? ???????? ???????? ???????????????????????????? ???????????????????? ????????????????????????, ?????????????????? ???????????????? ???????????????????????? ?? ?????????????????????? ?????? ???? ????????????????. ????????????????: ?????????? ?????????????????? ???? ?? ?????????????????? ?????????? ?????? ???????????? ???????????????????? ?? ?? ?????????????????? ?????????????????????????? ???????????????????? ???????????????? ???? ?????????????? ?????????????????????? ???? ?? ?????????????????????????????????????????? ?????????????????? ?????????????????????????????????????? ??????????????, ?? ?????????? ?????? ?????????????????????? ???????????????? ?????????????? ???? ???????????????????????? ???????????????????????????? ??????????????.

Aim: to investigate diagnostic significance and prognostic informativeness of the method of the galactomannan antigen (GA) detection in blood serum of pediatric patients with haematologic malignancies for early diagnosis of invasive aspergillosis (IA) and monitoring of antimicotic treatment efficacy. Objects and methods: 144 blood samples from immunocompromised pediatric patients were investigated. 95% were patients with haematologic malignancies. All patients underwent standard laboratory testing procedures, which included microbiological methods and computer tomography studies aimed at identifying the IA. Determination of the serum level of Aspergillus GA was performed using ELISA test kits ??Platelia Aspergillus Ag?? (Bio-Rad) once a week during the hospital stay and in the course of antimycotic therapy. Results: GA in the serum was detected in 7 of 144 patients. The diagnosis of IA in patients with present in the serum GA was confirmed by the results of computer tomographic study in 85.7% of cases. False negative results were absent. Number of false positive results was 3%. One of the causes of false positive results may be drug cross-reactivity caused by the treatment with piperacillin and tazobactam or its analogues. Conclusion: method of the detection of GA serum level has high sensitivity and is quite informative methodical approach for early diagnosis of IA in immunocompromised patients with haematologic malignancies as well as for the evaluation of the efficacy of antimycotic therapy.