?? ???????????? ?????????????????? ?????????????????????????? ?? ?????????????????????????????????? ???????????????????????????? ???????????????????????????????????????????????????????????????????? NMDA-???????????????????? ???????????????????? ?? ???????????????????? ?? ???????????????????????????????? ?????????????????????????? (???????????????????? ????????????, ??????????????????, ????????????????????, ????????????????????, ?????????????????????? ?? ??????????????????). ??????????????????????, ?????? ?????????????????? ?? ?????? ???????????????????? ?? ?????????????????????????? ???????????????? ???????????? ???? ???????????????????????? ???????????????????????? (???????????? ???????????????????????????????????? ?????????? ???????????? - ?????????????? ??????????????????????) ?? ?????????????????????????????? (???????????? ???????????????????????????? ????????????) ???????????????????? ???????????????????????? ?????????????????????????? ???????????? ?? ?????????????????? ????????????????. ?????????????????????? ???????????????????????????? ???????????????? ???????????????????? ?????????????????????????? ???????????????????? ?? ???????????? ??????????????????????????, ?????? ????????????????????, ?????????????????? ?? ????????????????????, ?????? ?????????? ?????????????????? ?????? ?????????????? ???????????????? ???????????????? ???????????????????? ????????????.

?? ???????????? ???????????????? ???????????????????? ?? ???????????????????????????????? ???????????????????????????? ???????????????????????????????????????????????????????????????????? NMDA-???????????????????? ???????????????????? ?? ???????????????????? ?? ???????????????????????????? ???????????????????????? (???????????????????? ????????????, ??????????????????, ????????????????????, ????????????????????, ?????????????????????? ?? ??????????????????). ??????????????????????, ???? ?????????????????? ?? ???????? ???????????????????? ?? ???????????????????????? ???????????? ???????????????? ???????????????????????? ???????????????????????? (???????????? ???????????????????????????????????? ???????????? ???????????? ??? ?????????????? ??????????????????????) ???? ?????????????????????????? (???????????? ?????????????????????????? ??????????????) ???????????????????? ???????????????????? ?????????????????????????? ?????????????????? ?? ?????????????????? ????????????. ???????????????????????????? ?????????????????????????? ?????????????????????? ???????????????????? ?????????????????????????? ???????????????????? ?? ???????????? ????????????????????????, ???? ????????????????????, ?????????????????? ?? ????????????????????, ???? ?????????????? ?????????????????????? ?????? ?????????????? ?????????????????? ???????????????? ?????????????? ????????????.

This work contains results of the analysis of theoretical and experimental data about probable activity of the inhibitor NMDA-receptors Amantadine, combined with non-narcotic analgetics (Diclofenac sodium, Nimesulide, Celecoxib, Parecoxib Paracetamole and Metamizole). We have determined that Amantadine and its combinations with analgetics are able to influence forming of central (modeling of electric irritation of the queue???s root ??? reaction of vocalization) and peripheral (modeling of convulsions, being induced by the acetic acid) components of the painful response, which intact rats have. The most effective activity belong to combinations of Amantadine with Celecoxib, Metamizole and Diclofenac sodium. This circumstance has to be considered having deal with pain of uncertain origin.