???????????????????? ?????????????????????????????????????? ?????????????????? ?? ?????????? ?????????????????????????????? ?????????????? ??????????????????????, ?????????????? ?????????????????????????????????? ?? ?????????? ???????????????????????? ??????????????. ?????????????? ???????????????????????????? ???????????????? ???????????????????? ?????????????????? ?? ???????? ??????????, ?????????????? ?????????????? ?????????????? ?? ???? ???????????????????? ?????????????????? ????????????????????????. ?????????????????????????????????????? ?????????????? ?????????????????? ?????????????????? ???????????????????? ?????????????? ?????? ???????????????? ???????? ?????????????????? ?? ????????????????. ???????? ?????????????????????? ?????????????????????????????? ?????????????? ?????????????????????????????????? ???????????????????? ???? ??????????????: ????????????????????, ?????????????????? ?? ???????????????????? ???? ???????????????????????????? ?????????????????? ?? ?????????? Drosophila melanogaster. ????????????????, ?????? ?????? ???????????????????? ?????????????? ???????? ???????????????????? ?????????????????????????????????????? ???????????????? ?? ?????????? ???????????????? ???????????????????????? ???? 17-20 ?????? ?????????? ??????????. ????????????????, ?????? ?????????????????????????? ???????????????????? ?????????????????? + ???????????????? + ?????????????????? ???????????????????? ?????????? ?????????????????? ???? 10-23 % ?? ?????????????????????? ???? ???????????????? ????????????????. ???????????????? ???????????????? ???????????? ???????????????????? ?? ?????????????????????????????????????? ???????????????? ?????????????????????? ?? ???????????????? ???????????????????????? ???????????????????????????????? ?????????????? ???? 20-45 % ???? ?????????????????? ?? ??????????????????.

???????????? ???????????????????????????????????? ?????????????????? ?? ???????????? ???????????????????????????????? ???????????? ??????????????, ?????????????? ???????????????????????????? ?? ?????????? ???????????????????????? ????????????. ?????????????????? ???????????????????????????? ?? ???????????????????? ??????????????????, ?????????????????? ???????? ???????????????? ?????? ???????????????????? ?????????????????? ????????????????????. ???????????????????????????????????? ?????????????? ?????????????????? ?? ???????????????????? ?????????????? ?????? ???????????????? ?????????????????????????????????????? ???????????????? ?? ????????????. ???????? ???????????????????? ???????????????????????? ?????????? ?????????????????????????????? ???????????????????? ???? ??????????????: ????????????????????, ?????????????????? ???? ???????????????????? ???? ?????????????????????????? ?????????? ?? ?????????? Drosophila melanogaster. ????????????????, ???? ???????????????????????? ???????????????????? ?????????????????? + ???????????????? + ?????????????????? ?????????????????? ?????????? ?????????? ???? 10-23 %, ?? ?????????? ?????????????????????????? ???????????????????????????????????? ?????????????? ?? ?????????? ???????????????? ???? 17-20 ?????? ?????????? ?????????? ?????????????? ?????? ????????????????. ???????????????? ?????? ?????????? ???????????????????? ???????????????????? ?? ?????????????????????????????????????? ???????????????? ??????????????, ?? ??????????????????, ?? ???????????????? ???????????????????????? ???????????????????????????????????????? ?????????????? ???? 20-45 % ?????????????????? ?? ??????????????????.

Various human neurodegenerative disorders are characterized by late onest, relentless progression and finally death. The neurodegenerative diseases treatment is actual problem nowdays. D. melanogaster neurodegenerative mutants are a good model for human neurodegeneration investigation. It was explored combine influence of pharmacological drugs piracetam, cerebral and verapamil on the degenerative processes in Drosophila melanogaster brain. We detected that share influence of this drugs delay changes in neurodegenerative mutants brain by 17-20 days. It was shown that piracetam, cerebral and verapamil combine influence enlarge mean lifetime by 10-23 % depending of mutants genotype. Share combination influens decreases intracellular ????^+2 iones concentration by 20-45 % comparativly control in neurodegenerative mutants.