Transportation networks face escalating challenges to cater to increased mobility demand while addressing traffic congestion. Traditional remedies, such as adding roads, can paradoxically worsen congestion, as seen in Braess’s paradox. This study emphasizes the potential benefits of strategically closing roads to alleviate congestion and carbon emissions. Milan serves as a case study, where various road closure strategies were tested to identify scenarios where strategic removal not only eased congestion but also significantly reduced CO2 emissions. The findings provide practical insights for urban planners and policymakers, offering a roadmap to develop more efficient and eco-friendly urban transportation systems.