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Article . 2023
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Frontiers in Immunology / Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2023 English Publisher:Frontiers
Authors: Hegen, Harald; Berek, Klaus; Cavalla, Paola; Christiansen, Mikael; Emeršič, Andreja; Di Filippo, Massimiliano; Gaetani, Lorenzo; +13 Authors

Frontiers in Immunology / Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

Abstract

Background: Kappa free light chains (k-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS). Objective: To investigate whether k-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB). Methods: Patients with PPMS were recruited through 11 MS centres across 7 countries. k-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation. Results: A total of 174 patients (mean age of 52±11 years, 51% males) were included. k-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients. Conclusion: k-FLC index shows similar diagnostic sensitivity than OCB in PPMS.

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Keywords

primary progressive, diagnosis, kappa free light chain, multiple sclerosis,, sensitivity, cerebrospinal fluid

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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