Introduction: The incidence of in-hospital cardiac arrest (IHCA) is 1.5–2.8/1,000 admissions, the survival is related to the area where it occurs, the response times, the assistance provided, and especially the initial rhythm of the IHCA. Materials and methods: Descriptive study about the impact of optimizing cardiorespiratory arrest (CPA) management through a continuous training program and the development and implementation of tailored checklists in a hospital emergency department (ED) to improve patient safety during CPA and reduce errors attributable to human factors. The continuous training consisted of advanced life support courses and annual refreshers provided to ED medical personnel, nurses, and residents, following the European Resuscitation Council (ERC) guidelines and using clinical simulation methodology. Results: Instructors have observed the acquisition of competencies by the staff and a positive progression in successive editions, reflected in the ability to handle more complex cases, improved role performance, and communication within the team, even with unplanned staff rotations, as analyzed in the debriefings course. A comprehensive CPA management protocol has been developed, previously assisted by the Intensive Care Unit, providing the ED with greater autonomy. Conclusion: Periodic training and checklists allow for the optimization of CPA management, reducing the insecurity of those leading the effort, minimizing errors attributable to human factors, and facilitating the analysis of interventions performed during resuscitation.