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Cerebrovascular disease: Pharmacological properties and efficacy of dipiridamol as a medicament with pleiotropic action mechanism

Authors: Cheltsov V.V.; Martynov A.I.;

Cerebrovascular disease: Pharmacological properties and efficacy of dipiridamol as a medicament with pleiotropic action mechanism

Abstract

Main clinical-pharmacological effects of dipiridamol action are considered in the context of its use in case of cerebrovascular disease. The vasodilatating effect of the medicine, antioxidative effect and ability to improve tissue perfusion are accentuated. The results of experimental and clinical research work reflecting efficacy and safety of dipiridamol are introduced. Pleiotropic action mechanism of the medicament whicht makes it possible to have a complex influence at pathogenetic factors of cerebrovascular disease is noted.

Рассмотрены основные клинико-фармакологические эффекты дипиридамола в контексте его применения при цереброваскулярной болезни. Сделан акцент на вазодилатирующем действии препарата, его способности улучшать перфузию тканей и антиоксидантном эффекте. Приведены результаты экспериментальных и клинических исследований, отражающих эффективность и безопасность дипиридамола. Отмечен плейотропный механизм действия препарата, позволяющий достичь комплексного воздействия на патогенетические факторы цереброваскулярной болезни.

Keywords

плейотропные эффекты, dipyridamole, антиагреганты, antiaggregants, pleiotropic effects, дипиридамол

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green