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Antioksidansi kao preventivna terapija urolitijaze u staničnom modelu

Authors: Kizivat, Tomislav; Smolić, Martina; Smolić, Robert; Bilić-Ćurčić, Ines; Roguljić, Hrvoje; Milas-Ahić, Jasminka; Včev, Aleksandar; +1 Authors

Antioksidansi kao preventivna terapija urolitijaze u staničnom modelu

Abstract

Urolitijaza je karakterizirana stvaranjem solidnih depozita unutar renalnog sustava. Postoje brojni uzroci nastanka bubrežnih kamenaca. Većina kamenaca sastavljena je od kalcijevog oksalata, koji stvara slobodne radikale te time uzrokuje oksidativno opterećenje i oštećenje endotelnih stanica bubrega. Oštećenje endotelnih stanica zajedničko je većini pretpostavljenih modela nastanka kamenca. Cilj ovog istraživanja bio je istražiti utjecaj antioksidanasa (vitamina E i L-arginina) na prevenciju oksidativnog opterećenja u endotelnim stanicama sabirnog tubula bubrega. MDCK I korištene su kao invitro model sabirnog tubula bubrega. Kako bi prevenirali oksidativni stres u stanicam uzrokovan 8mM natrijevim oksalatom, stanice smo predtretirali rastućim koncentracijama vitamina E i L-arginina te smo stanično preživljenje odredili brojanjem stanica.

Keywords

antioksidansi, antioxidants, MDCK I stanični model, bubrežni kamenci, urolithiasis, MDCK I cell model

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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