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Mice as Animal Model for Evaluation of Therapeutic Efficacy of Preparations against Monkeypox

Authors: Al. A. Sergeev; A. S. Kabanov; L. E. Bulychev; O. V. P’Yankov; Ar. A. Sergeev; O. S. Taranov; S. A. Bodnev; +4 Authors

Mice as Animal Model for Evaluation of Therapeutic Efficacy of Preparations against Monkeypox

Abstract

of MPV after 7 days postinfection, applying peroral administration once within 24 hours (24 hours before infection and 7 days after infection of mouse with 60 µg/g of a preparation). Displayed is the feasibility of using 8–15-days-old ICR mice (body weight 9–11 g) as an animal model for evaluation of therapeutic efficacy of the preparations under development against Monkeypox and smallpox.

Keywords

50 % infective dose, animal model, intranasal infection, вирус оспы обезьян, Infectious and parasitic diseases, RC109-216, мышь, модельное животное, monkeypox virus, preparations against monkeypox, противооспенные препараты, клинические признаки, clinical signs, 50 % инфицирующая доза, интраназальное инфицирование, mouse

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
gold